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D-α-Tocopherol succinate CAS# 4345-03-3

  • D-α-Tocopherol succinate CAS# 4345-03-3
  • D-α-Tocopherol succinate CAS# 4345-03-3
  • D-α-Tocopherol succinate CAS# 4345-03-3
  • D-α-Tocopherol succinate CAS# 4345-03-3

D-α-Tocopherol succinate CAS# 4345-03-3
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D-α-Tocopherol succinate CAS# 4345-03-3
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Chemical Name：D-α-Tocopherol succinate
CAS No.: 4345-03-3
Molecular Formula：C33H54O5
Sample: Available
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D-α-Tocopherol succinate CAS# 4345-03-3

Tocopherol succinate (4345-03-3) is a potent antioxidant.  Protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.1,2? Tocopherol succinate induces apoptosis in human gastric cancer cells3? and inhibits proliferation of mesothelioma cells by down-regulation of fibroblast growth factor receptor-14.  Induces apoptosis in neuroblastoma cells.5

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D-α-Tocopherol succinate Chemical Properties

Melting point

~76 °C(lit.)

Boiling point

625.8±55.0 °C(Predicted)

density

1.002±0.06 g/cm3(Predicted)

vapor pressure

0Pa at 20℃

storage temp.

-20°C

solubility

Practically insoluble in water, very soluble in methylene chloride, soluble in acetone and in anhydrous ethanol.

form

Solid

pka

4.35±0.17(Predicted)

color

White or off-white

Odor

Little or no odor

biological source

synthetic

λmax

286nm(EtOH)(lit.)

Merck

14,9495

BRN

4038233

Specific Activity

1210IU/g

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

LogP

12 at 25℃

CAS DataBase Reference

4345-03-3(CAS DataBase Reference)

EPA Substance Registry System

D-.alpha.-Tocopheryl acid succinate (4345-03-3)


Safety Information

WGK Germany

1

RTECS

EJ9984000

F

8-10-23

HS Code

2936280000

Toxicity

LD50 oral in rat: > 7gm/kg


Product Usage

A potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines.

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