Trifluoroacetamide CAS#354-38-1

Trifluoroacetamide has a melting point of approximately 72-75℃ and a boiling point of about 162-164℃. It is readily soluble in water, ethanol, ether and other polar organic solvents. It possesses the typical chemical properties of amide compounds. Meanwhile, due to the presence of trifluoromethyl (-CF₃), it has certain stability and special reactivity. For instance, in organic synthesis, it can be used as an acylation reagent or a protecting group.

Product Usage

2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups.