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Paclitaxel#33069-62-4

  • Paclitaxel#33069-62-4
  • Paclitaxel#33069-62-4
  • Paclitaxel#33069-62-4
  • Paclitaxel#33069-62-4

Paclitaxel#33069-62-4
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Paclitaxel#33069-62-4
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Chemical Name：Paclitaxel
CAS No.:33069-62-4
Molecular Formula：C47H51NO14
Sample: Available
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Paclitaxel#33069-62-4

Paclitaxel, a natural product isolated from the bark of the Pacific yew, is effective in treating refractory metastatic ovarian cancer.  Unlike any other antineoplastic agents, paclitaxel appears to have several possible mechanisms of action, including an antimicrotubule action through the promotion of tubulin polymerization and stabilization of microtubules, thereby, halting mitosis and promoting cell death.


Paclitaxel Chemical Properties


Melting point

213 °C (dec.)(lit.)

alpha

D20 -49° (methanol)

Boiling point

774.66°C (rough estimate)

density

0.200

refractive index

-49 ° (C=1, MeOH)

Fp

9℃

storage temp.

2-8°C

solubility

methanol: 50 mg/mL, clear, colorless

form

powder

pka

11.90±0.20(Predicted)

color

white

Water Solubility

0.3mg/L(37 ºC)

λmax

227nm(MeOH)(lit.)

Merck

14,6982

BRN

1420457

Stability:

Stable. Incompatible with strong oxidizing agents. Combustible.

InChIKey

RCINICONZNJXQF-MZXODVADSA-N

LogP

3.950 (est)

CAS DataBase Reference

33069-62-4(CAS DataBase Reference)

EPA Substance Registry System

Paclitaxel (33069-62-4)



Safety Information


Hazard Codes

Xn

Risk Statements

37/38-41-42/43-62-68-40-48-20/21/22-68/20/21/22

Safety Statements

22-26-36/37/39-45

RIDADR

1544

WGK Germany

3

RTECS

DA8340700

F

10-21

HazardClass

6.1(b)

PackingGroup

III

HS Code

29329990

Hazardous Substances Data

33069-62-4(Hazardous Substances Data)

Toxicity

LD50 intraperitoneal in mouse: 128mg/kg


Product Usage

Paclitaxel is an antineoplastic that used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanc ed forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It is also used in the study of structure and function of microtubles into tubulin.

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